Derived from Spirulina using a proprietary aqueous extraction method, CyaninPlus is a novel ingredient that supports a healthy inflammation response through a 5-pronged mechanism of action.* Because it is clinically shown to relieve physical discomfort, CyaninPlus helps consumers feel better, do more, and enjoy a better quality of life.* This brilliant blue extract contains both phycocyanin (PC) and non-PC compounds—a concentrated combination not seen in standard Spirulina powder or phycocyanin—which contributes to its unique efficacy.


CyaninPlus is:

  • Substantiated: Backed by solid scientific research on the actual ingredient itself

  • All-natural: Derived from natural sources and free of synthetic additives

  • Specially extracted: Extracted through a proprietary aqueous extraction method that concentrates the bioactive constituents without the use of chemical solvents or buffers

  • Triple-certified: Available as both an all-natural and as a certified organic (Oregon Tilth Certified Organic) form, all forms are kosher/pareve (Rabbi Zushe Yosef Blech) and Halal (IFANCA)

  • Brilliant blue: Signifies strong antioxidant activity and arouses consumer interest

  • GRAS: FDA GRAS: Notice No. GRN 000424

  • Pure: Source material is tested to comply with industry standards for heavy metals, pesticides, and microbes

  • Versatile: Can be used as a free-standing ingredient or blended with other materials for a synergistic effect

Health Benefits

CyaninPlus has been the subject of original in vitro and human clinical research showing that it:

  • Modulates natural inflammatory responses*
  • Promotes healthy joints*
  • Reduces general discomfort*
  • Provides greater physical comfort at rest and during everyday activities*
  • Provides antioxidant and cellular protection and support*

Review preclinical and clinical research studies on CyaninPlus.

Mechanisms of Action

Inflammation is a double-edged sword. While short-term inflammation is a necessary and healthy response to injury, inflammation caused by prolonged stressors can result in physical discomfort and ongoing health challenges. CyaninPlus is the body's rebalancing tool, helping to modulate a healthy inflammation response.*

Understanding the Inflammation Reaction Cascade

The inflammatory response to a threat (whether real or perceived, i.e., mental stress) is a complex interaction of events that build upon and perpetuate each other, which is why it is called a “reaction cascade.” The following physiological responses take place during a reaction cascade:

  • The body increases its production of enzymes COX-2 and lipoxygenase (LOX), which produce signaling compounds
  • COX-2 and LOX recruit more blood cells and molecules to the site of injury and increase the production of inflammatory prostaglandins
  • These prostaglandins trigger nerves to signal pain and discomfort in the area
  • Meanwhile, a wave of inflammatory chemicals increases the cellular production of free radicals, including reactive oxygen species (ROS)
  • Increased levels of ROS create a state of oxidative stress in the body, which can set the stage for potential health challenges

CyaninPlus's 5-Pronged Inflammation Modulation


CyaninPlus 5-pronged inflammation modulation

Mechanism-of-action research conducted by Desert Lake Technologies has shown that CyaninPlus 

helps rebalance the body and support a healthy inflammation response
through a 5-pronged mechanism of action. CyaninPlus:

  1. Inhibits COX-2 enzyme activity*
  2. Inhibits lipoxygenase (LOX) enzyme activity*
  3. Reduces production of prostaglandins*
  4. Inhibits cellular production of free radicals*
  5. Protects cells from oxidative stress and ROS by quenching free radicals*

Product Characteristics



Arthrospira platensis or maxima Blue-green Algae Water Extract












platensis or maxima


Physical Characteristics




Ground powder (2-70 mesh)



Brilliant Blue  


Odor / Taste

Slight Marine



≤ 7%

Cerule QUAL-S169

Tapped Density

For Information Only

Cerule QUAL-S170


≥ 30 %

Cerule QUAL-S153




Total Plate Count

Less than 50,000 cfu/g

Cerule QUAL-S101

Total Coliforms

Less than 10 cfu/g        

Cerule QUAL-S101

Mold & Yeast

Less than 1,000 cfu/g

Cerule QUAL-S101

S. Aureus

Less than 10 cfu/g

Cerule QUAL-S101

E. Coli

Negative / 1 gram

Cerule QUAL-S101


Negative / 25 grams





Microcystin Toxin

None Detected

Cerule QUAL-S113

Arsenic Inorganic

Not more than 1 ppm

AOAC 993.14


Not more than 1 ppm

AOAC 993.14


Not more than 1 ppm

AOAC 993.14


Not more than 0.5 ppm

AOAC 993.14

Organophosphorus Pesticides

None Detected


Organochloride Pesticides

None Detected

EPA 8081B, 8141B, 8270D, 8321B

Pyrethroid Pesticides

None Detected


Regulatory Status & Safety


Stability Considerations                



Incompatibility with



Hazardous Decomposition Products

None known


Special Fire Fighting Procedures



Unusual Fire and Explosion Hazards



Hazardous Polymerization

Will not occur


Spill / Leakage Procedures

If material is released or spilled: sweep up with broom and discard. Water disposal method: Dispose of in accordance with local, state and Federal regulations as regards fruit, seed and vegetable handling.


Worker Skin Protection

Normal work wear


Worker Eye Protection

Goggles are recommended in all manufacturing environments


Primary Route of Exposure



Effects of Over Exposure



Emergency First Aid Procedures

Flush eyes with large quantities of water, rinse, rinse other areas with soap and water. Drink large amounts of water.


Drying Method, Packaging, Storage, Shelf Life


Drying Method

DLT Hydro•Dri® or spray dry 



10 kg poly lined, Mylar bag, vacuum packaged


Storage Conditions

Store in cool dry place, away from extreme conditions of heat, cold and moisture to prevent oxidation and preserve quality. Do not store this product above 70F. Store in airtight containers away from most sources of light and heat.


Shelf Life

Retest at 36 months from date of manufacture




Available Forms

Ground powder


Typical Dose

1 gram per day


What is CyaninPlus?

CyaninPlus is a novel, bright-blue ingredient extracted from spirulina through a proprietary aqueous extraction method. Mechanism-of-action research performed by Desert Lake Technologies shows that CyaninPlus supports a healthy inflammation response through a 5-pronged mechanism of action.* In addition, human clinical research documents that CyaninPlus promotes healthy joints, reduces general discomfort, and provides greater physical comfort during everyday activities.*

How is CyaninPlus different from crude spirulina?

Spirulina is often referred to as nature’s “perfect food” because its nutrients—antioxidants (including phycocyanin), protein with a complete amino acid profile, PUFAs (including GLA), vitamins and minerals—have such high biological value. CyaninPlus is a proprietary extract that advances the bioactivity of spirulina by removing the majority of its non-soluble components and more than doubling its phycocyanin (PC) content. In addition, it also includes other soluble bioactive components that work synergistically with PC to enhance the ingredient’s benefits.

What is phycocyanin?

Brilliant blue in color, phycocyanin is a naturally occurring pigment in spirulina. This compound has inflammation-modulating, antioxidant, and healthy aging properties that have been documented in many open-source scientific publications and through original Desert Lake Technologies human clinical research.*

Why is CyaninPlus better than concentrated phycocyanin extracts?

Phycocyanin (PC) is one of the most important bioactive constituents of spirulina, but it is not the only one. In addition to PC, CyaninPlus contains other blue-green algae-derived compounds that work synergistically with PC for a more powerful effect. In fact, CyaninPlus has been shown to inhibit both COX-2 and lipoxygenase (LOX)—the two main enzymes responsible for initiating the inflammation reaction cascade—thereby promoting increased comfort throughout the body.* This dual-action is due to the unique molecular makeup of CyaninPlus and cannot be achieved with phycocyanin alone.

Is CyaninPlus clinically researched?

Yes! CyaninPlus has been the subject of three human studies—including two placebo-controlled trials—showing it improves physical discomfort in joints and muscles, reduces general discomfort associated with inflammation, and increases the ability to perform daily activities.*

How does CyaninPlus work?

CyaninPlus helps rebalance the body and support a healthy inflammation response through a 5-pronged mechanism of action.*

Why is CyaninPlus bright blue?

Spirulina is a type of blue-green algae. The green color comes from chlorophyll, while the blue hue is due to the pigment phycocyanin—a compound with powerful biological activity. CyaninPlus is selectively extracted to concentrate the phycocyanin content of spirulina, thus resulting in its brilliant blue color.

What type of supplements is CyaninPlus suited for?

Because of its 5-pronged inflammation modulation, CyaninPlus is perfect for supplements aimed at reducing general discomfort associated with inflammation such as joint health and sports recovery supplements.* CyaninPlus’s documented ability to neutralize existing free radicals and help prevent the formation of new free radicals makes it an excellent choice for anti-aging supplements.*

How has CyaninPlus’s antioxidant capacity been demonstrated?

CyaninPlus’s antioxidant capacity has been tested in parallel assays, including:

  • Folin-Ciocalteu assay (tests chemical antioxidant capacity)
  • Cellular Antioxidant protection (CAP-e) assay
  • Polymorphonuclear (PMN) cell assay (inhibition of ROS)

The results of these parallel assays indicate that both the phycocyanin (PC) and non-PC components of CyaninPlus exhibit strong antioxidant capacity, but the CAP-e assay indicates that, when combined, the non-PC and PC fractions provide greater cellular protection than either fraction alone. The researchers concluded that the synergistic effects of CyaninPlus’s proprietary formula increased the antioxidant properties of CyaninPlus above PC alone.

Is CyaninPlus safe?

Yes! CyaninPlus is derived from spirulina, which has been safely consumed as part of the food supply for hundreds of years. The source material is tested to comply with industry standards for heavy metals, pesticides, and microbes. CyaninPlus is manufactured through a proprietary aqueous extraction process that concentrates the bioactive constituents without the use of chemical solvents or buffers. It is FDA GRAS.

Is CyaninPlus made in the USA?

Yes! Desert Lake Technologies manufactures CyaninPlus at our state-of-the-art manufacturing facility located in Klamath Falls, Oregon, which is situated near the beautiful Cascade Mountains.

Is organic CyaninPlus available?

Yes! Our organic CyaninPlus has been farmed and harvested to meet USDA National Organic Program standards.